Harnessing shared antigens and T-cell receptors in cancer: Opportunities and challenges
نویسندگان
چکیده
منابع مشابه
Harnessing shared antigens and T-cell receptors in cancer: Opportunities and challenges.
Blockade of inhibitory immune checkpoints (ICPs) has led to impressive clinical regressions in some patients with tumors like lung cancer or melanoma, which often carry a high mutational load (1). Somatic mutations expressed by tumor cells can provide a rich source of neoantigens, and it has been suggested that T cells against these antigens may be targets of ICP blockade (2, 3). Because the ta...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1608860113